| Title: | Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice) |
| Author: | Rajasalu, Tarvo |
| Abstract: | In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified. |
| URI: | http://hdl.handle.net/10062/3991 |
| Date: | 2007-10-04 |
| Files | Size | Format | View |
|---|---|---|---|
| Rajasalu_Tarvo.pdf | 3.028Mb |
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